With the forceps biopsy some membranes are removed. It is one of the syndromes associated with iron deficiency anemia. Plummer vinson syndrome classically presents as a triad of irondeficiency anaemia, postcricoid dysphagia and upper esophageal webs. Symptoms resulting from anemia predominates the clinical picture, apart from the additional features such as glossitis, angular cheilitis, and dysphagia. Pvs can easily be treated and effectively with iron supplements and mechanical dilation. Disease definition plummer vinson or siferopenica syndrome presents as a classical triad of dysphagia, irondeficiency anemia and esophageal webs. Plummervinson syndrome can be treated effectively with iron.
People with this condition have problems swallowing due to small, thin growths of tissue that partially block the upper food pipe esophagus. Plummer vinson syndrome pvs is a rare condition characterized by classical triad. Definition plummervinson syndrome pvs is a classical triad of postcricoid dysphagia, upper esophageal webs, and iron deficiency anemia. Plummervinson or patersonkelly syndrome presents as a classical triad of dysphagia, irondeficiency anemia and esophageal. In case of significant obstruction of the esophageal lumen by esophageal web and persistent dysphagia despite iron supplementation, rupture and dilation of the web are necessary. Kelly syndrome pvs is a rare entity comprising upper esophageal webs and iron deficiency anemia.
For the past 5months, she has felt extreme fatigue, shortness of breath, and palpitations on exertion. Department of medicine, university of california, san diego, california. They are thought of as a precancer as the risk of squamous cell carcinoma of the esophagus and pharynx is increased. A rare case report on plummervinson syndrome with a. Treatment includes correction of iron deficiency and endoscopic dilation of the esophageal webs to relieve dysphagia.
Plummervinson syndrome an overview sciencedirect topics. Plummer vinson syndrome, if left untreated, carries an increased risk of developing squamous cell carcinoma of the upper alimentary tract. Esophagus patersonbrownkelly or plummervinson syndrome. Plummervinson or patersonkelly syndrome presents as a classical triad of dysphagia, iron deficiency anemia and esophageal webs. Plummer vinson syndrome pvs, also known as patersonkelly syndrome or sideropenic dysphagia, is a rare pathology combining dysphagia, iron deficiency anemia and cervical esophageal web. Plummer vinson syndrome \pvs\ is a rare condition characterized by classical triad. The first step in the management of plummervinson syndrome is to clarify the cause of iron deficiency in order to. Get a printable copy pdf file of the complete article 533k, or click on a page image below to browse page by page.
Although most cases have a benign and indolent course, the risk of malignancy warrants longterm surveillance. Plummer 18741937 and surgeon porter p vinson 18901959. A barium esophagram figure below will confirm the diagnosis. Data regarding this condition is limited to mostly case reports and a few small cohort studies. Figure 2 summary of pathophysiology for plummervinson syndrome.
Pmr secrets pdf plummer vinson or patersonkelly syndrome presents as a. In adults, iron supplementation is frequently sufficient to control dysphagia. Treatment with iron supplementation and mechanical widening of the esophagus generally provides an excellent outcome. Data regarding this condition is limited to mostly case reports and a. Plummervinson syndrome can be treated effectively with iron supplementation and mechanical dilation. We report a case of pvs in a 62yearold patient admitted to the department of gastroenterology an\ d internal medicine for high dysphagia. Plummervinson syndrome a rare presentation in a child. Plummer vinson syndrome pvs is named after henry stanley plummer and porter paisley vinson, who were physicians on the staff of the mayo clinic. Plummervinson syndrome atmatzidis 2003 diseases of. Full text full text is available as a scanned copy of the original print version. Even though the syndrome is very rare nowadays, its recognition is important because it identifies a group of patients at increased risk of squamous cell carcinoma of the pharynx and the esophagus. The cuplike or spoonlike depression of the nail is centrally located, and may be of such a degree that a.
Plummer vinson syndrome pvs is a rare pathology combining dysphagia, an iron deficiency anemia and a cervical esophageal web. Management and treatment plummer vinson syndrome can be treated effectively with iron supplementation and mechanical dilation. Revisiting plummer vinson syndrome a report of three cases. Elemental iron in the range of 150200 mg is required for correction of iron deficiency anemia which in most cases corrects. Plummervinson syndrome and esophageal cancer in an. Pvs is commonly found in women of middle age especially in the fourth and fifth decade of life and is rarely reported in males. Plummer vinson syndrome also known as paterson brownkelly syndrome is a syndrome associated with the triad of symptoms comprising microcytic hypochromic anemia, oesophageal strictures, and dysphagia. In this case report, a 40yearold female patient presented longstanding dysphagia for months, which progressively developed to postcricoid squamous cell carcinoma by the time she approached to medical. It is one of the risk factors of the esophageal cancer. The esophageal webs of plummervinson syndrome are usually in the upper esophagus and more common in women. Having trouble remembering all the important questions to ask during your patient encounter. Both patients presented with dysphagia, anemia, sideropenia, glossitis and cheilitis. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Pdf plummervinson or patersonkelly syndrome presents as a classical triad of dysphagia, irondeficiency anemia and esophageal webs.
Plummer vinson or patersonkelly syndrome presents as a classical triad of dysphagia, irondeficiency anemia and. Plummervinson syndrome is a rare condition associated with dysphagia, iron deficiency, and esophageal webs. The association of postcricoid dysphagia, upper esophageal webs, and iron deficiency anemia is known as plummer vinson syndrome pvs in the united states and patersonbrown kelly syndrome in the united kingdom. Links to pubmed are also available for selected references. To report the epidemiological, clinical, paraclinical and histological characteristics of patients with plummer vinson syndrome associated with esophageal cancer.
As described above, dysphagia and anemia can be treated effectively. Pdf plummervinson or patersonkelly syndrome presents as a classical triad of dysphagia, iron deficiency anemia and esophageal webs. Plummervinson syndrome is a condition that can occur in people with longterm chronic iron deficiency anemia. Plummer vinson syndrome symptoms, diagnosis, treatment. Revisiting plummer vinson syndrome annals of medical and. The depletion of irondependent oxidative enzymes may produce myasthenic changes in muscles involved in the swallowing mechanism, atrophy of the oesophageal mucosa. Dysphagia is defined as an inefficiency in transferring food, liquid, or saliva from the oral cavity to the stomach tjaden, 2008 and is a common symptom among pd patients, tending to develop after the appearance of dysarthria, which. Fahmi yousef khan, a haleem elhiday and nader a morad. Plummervinson syndrome orphanet journal of rare diseases. Plummer vinson or patersonkelly syndrome presents as a classical triad of dysphagia, iron deficiency anemia and esophageal webs. Prognosis of the plummervinson syndrome is excellent.
Summary plummer vinson syndrome is characterized by dysphagia, iron deficiency, anemia and the presence of esophageal web or webs. Plummervinson syndrome with simultaneous midesophageal growth mukesh nasa1, gaurav patil 2, zubin sharma, rajesh puri3 abstract patterson brown kelly or plummer vinson syndrome is characterized by dysphagia, iron deficiency anemia and postcricoidal esophageal web. In cases in which spoon nails seem to be associated with some or all of the various components of the plummer vinson syndrome, the most constant finding is that of an associated anemia. Plummer vinson syndrome treatment the first step in the management of pvs is to make clear the cause for the iron deficiency so as to exclude any active bleeding, malignancy or celiac disease. Gerlings skip to main content we use cookies to distinguish you from other users and to provide you with a better experience on our websites. In 1912, plummer reported a series of twenty one patients with longstanding iron deficiency anaemia, dysphagia and spasm of the upper oesophagus without anatomic. Plummer vinson syndrome is a rare cause of dysphagia in children because of an upper esophageal web. In adults, plummer vinson syndrome may be associated with iron deficiency or diverse inflammatory disorders. Identification and followup is relevant due to increased risk of squamous cell carcinomas of the esophagus and pharynx. Get a printable copy pdf file of the complete article. Plummer vinson paterson, brownkelly syndrome refers to the association of irondeficiency anaemia with dysphagia secondary to a postcricoid web. We report a case of pvs in a 62yearold patient admitted to the department of gastroenterology and internal medicine for high dysphagia. Full text iron deficiency anemia and plummervinson syndrome.
Plummer vinson syndrome pvs is a triad of microcytic hypochromic anemia, atrophic glossitis, and esophageal webs or strictures. Plummer vinson syndrome is a rare condition associated with dysphagia, iron deficiency, and esophageal webs. Patients must be screened regularly for any development of upper gastrointestinal malignancy. The pathogenesis of plummer vinson syndrome remains speculative. Treatment is iron supplementation and, if need be, dilation of the web to permit normal swallowing and the passage of food. It typically affects middle aged females who may have other features of chronic iron deficiency, namely papillary atrophy of the tongue, spoon shaped brittle nails, angular stomatitis and pica.
The clinical examination showed anemic syndrome, general impairment and polyarthritis. In case of an associated squamous cell carcinoma of the hypopharynx or upper esophagus the prognosis worsens dramatically. The importance of the plummer vinson syndrome in the aetiology of carcinoma of the upper gastrointestinal tract. Various reports have shown that treatment of iron deficiency anemia. What hiring strategies have worked for you in this covid19 pandemic era. A 56yearold woman has had dysphagia and odynophagia for 2months. Only seven cases of plummer vinson syndrome in children and adolescents between the ages of 14 and 19 have been reported in the world literature. She has difficulty with initiation of swallowing and pain in the throat. Data regarding this condition is limited to mostly case reports and a few small cohort. Treatment of the iron deficiency frequently relieves dysphagia though some patients may need endoscopic web dilatation. Plummervinson syndrome is a rare disease characterized by difficulty swallowing, irondeficiency anemia, glossitis, cheilosis and esophageal webs. Being common in northern countries in the early twentieth century, it has become very rare nowadays.
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